Medical Researches
Possibly Effective
Based on 48 Researches
We examined how a special probiotic mix, known as IRT5, affects autoimmune diabetes in non-obese diabetic (NOD) mice. Administered frequently over 36 weeks, this combination not only reduced diabetes incidence but also lowered insulitis scores and increased insulin-producing β-cell mass.
Additionally, IRT5 improved gut health and changed the makeup of immune cells in the pancreas and intestines. While some immune responses stayed the same, the shift towards more gut-focused regulatory T cells suggests it could be a promising treatment for type 1 diabetes.
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Synbiotics improve rheumatoid arthritis symptomsSynbiotic supplementation and the effects on clinical and metabolic responses in patients with rheumatoid arthritis: a randomised, double-blind, placebo-controlled trial.
High relevance; significant findings
We investigated how synbiotic supplementation affects patients with rheumatoid arthritis (RA). In an 8-week, randomized, double-blind trial involving 54 participants, we compared the outcomes of those taking synbiotic capsules with a placebo group.
After the trial, those who received synbiotics showed a significant drop in inflammation markers and pain levels. Additionally, improvements were observed in insulin resistance and overall metabolic responses.
These findings suggest that synbiotics might benefit individuals managing RA by reducing inflammation and enhancing metabolic health.
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We explored how specific Lactobacillus acidophilus strains can impact autoimmune disorders by reducing leptin production in mice. In our study, we compared the effects of CBA4P and other lactobacilli on adipocytes from mice sensitive to Th1 immune diseases.
Results showed that CBA4P significantly lowered leptin levels and inhibited the activation of immune lymphocytes in the SJL mouse strain. This suggests that CBA4P might help manage Th1-related inflammatory conditions, representing a potentially valuable probiotic option for autoimmune control.
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We examined how probiotics, specifically Lactobacillus rhamnosus, could help with rheumatoid arthritis (RA) symptoms. By isolating monocytes from RA patients and healthy individuals, we created macrophages and tested various treatments.
Our findings revealed that probiotics encouraged macrophages to adopt a more anti-inflammatory state. They increased beneficial cytokines while lowering inflammatory ones. This suggests a potential role for probiotics in managing RA, showing they might help modulate immune responses and improve symptoms.
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LC-STH-13 counters lupus effects LC-STH-13 ameliorates the progression of SLE in MRL/lpr mice by inhibiting the TLR9/NF-κB signaling pathway.
High relevance, promising findings
We explored the effects of probiotic LC-STH-13 on systemic lupus erythematosus (SLE) in MRL/lpr mice. Our study demonstrated that LC-STH-13 significantly decreased harmful autoantibodies and rebalanced specific immune cells.
We also observed reduced immune cell infiltration in kidney tissue, indicating less inflammation. Furthermore, the probiotic helped restore healthy gut microbiota which gets disrupted by SLE. These findings suggest that LC-STH-13 may offer a novel way to manage lupus by targeting both immune regulation and gut health.
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User Reviews
Medium or Average
Based on 13 Reviews
Taking this probiotic has greatly aided my autoimmune disorder, particularly with its Lactobacillus rhamnosus strain, which is known to combat c. difficile infections. I used it before, during, and after my surgery while on antibiotics, and thankfully experienced no issues. I've since made it a part of my daily routine. It deserves its 5-star rating, and I wholeheartedly recommend it.
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This is the best probiotic for my autoimmune disorder! Suggested by my doctor, it helped reduce my reliance on Immodium within just two days. My gastrointestinal issues have significantly improved, allowing me to lead a normal life. I'm eagerly awaiting my next order to continue the improvements.
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This probiotic is fantastic! We use it regularly after antibiotic courses, during colds, and after gastrointestinal issues, aiding recovery from autoimmune disorders. It's more effective with long-term use, ideally taken at night on an empty stomach. We're sticking with this product, and I highly recommend it.
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This product significantly helps with my autoimmune disorders. It took over two months to notice effects, but now, taking three capsules daily, my symptoms have improved considerably. I will certainly continue using these capsules.
This product was beneficial for my autoimmune disorder, enhancing my digestion. I reordered quickly due to its effectiveness and the swift delivery.